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Scand J Rheumatol

Pyridoxine is often included when someone reports mood changes, difficulty with protein digestion, or low energy

J Nutr Intermed Metab 11:913 Khan A, Shafiq I, Hassan Shah M (2017) Prevalence of vitamin B12 deficiency in patients with type II diabetes mellitus on metformin: a study from Khyber Pakhtunkhwa

A 2025 meta-analysis pooling three trials (878 participants) confirmed the pattern: significantly greater weight loss than placebo about ~14% of total body weight on average with no significant rise in overall adverse events [6] [7]